If the content of cholesterol in the body too much then it will be easily attached to the walls of blood vessels, particularly the walls of blood vessels, particularly the inner walls of blood vessels. When a settlement like this then the LDL you will easily get into the blood vessel walls through the endothelial cell layer. Up in the endothelial layer, the LDL will go deeper into the intima. If the LDL size was smaller and more densely packed, it is not difficult to get in and infiltrate into the intima. LDL is also called small dense LDL.
When it came to the intima or the innermost layer of blood vessels, it will oxidize first stage. As a result, it becomes oxidized LDL. Oxidized LDL is what spurred the emergence of a substance that attaches and attract monocytes (a type of white blood cell) that can pass through the endothelial layer and into the intima. In that oxidized LDL can produce substances that are able to change different monozit into macrophages in the intima.
Meanwhile, oxidized LDL is oxidized completely. At this stage, completely oxidized LDL. The results of this oxidation can produce foam cells. Foam cells will bind themselves together to form clots. Clumps of the longer will be the greater. The result is the formation of lumps. With this lump, the blood vessels to narrow.
If the condition was getting worse over the bump it is not difficult to oxidized LDL perfectly so that it can stimulate the muscle cells in the lining of blood vessels deeper. Stimulation of these make LDL go deeper (intima) and developed in. During this development period, LDL will divide that number is growing.
Based on the explanation above, it can be said that the blockage was not easy. Therefore, you need to be vigilant when cholesterol levels in the body are in large numbers. Because when a lot cholesterol levels, the process of blood vessel blockage will be easier. Moreover, if a growing LDL cholesterol known as bad cholesterol. Please be aware that if the content of small dense LDL more and more, it will be very dangerous. The number of small dense LDL in the blood characterized by Apo-B levels were also high. Besides that, it is usually accompanied by low cholesterol levels.
So LDL is dangerous, but the small dense LDL is more dangerous because it was he who spurred the formation of lumps of various mechanisms of blood vessel walls or in medical terms is called atheroma.
The process normally inhibited LDL oxidation by the antioxidant system present in everyone's body. But when the body's antioxidant system is inadequate LDL oxidation process will continue to run. Adequacy of one's body's antioxidant system to counteract the process can be seen from the examination or the total antioxidant status and levels of SOD and GPX.
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